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In particular, metabolic disorders including diabetes, obesity, and hyperlipidemia commonly associated to hypercaloric diets are suspected to affect a woman's fertility either by direct damage to oocyte health and differentiation, or by indirect interference with the pituitary-hypothalamic axis, resulting in dysfunctional oogenesis

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ROS can modify sperm proteins through the oxidation of amino acid side chains, leading to the formation of carbonyl groups and disulfide bonds

Moreover, the combination of nanomaterials and hydrogels with plant bioactive metabolites further enhances the therapeutic effect, suggesting that PCs hold great promise for the treatment of DFU