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In general, Mind Lab Pro worked the best on reaction time, anticipation, memory recall, and information processing (particularly among the 30-and-over crowd).33 Onnits Alpha BRAIN has two studies under its belt, both of which are somewhat mixed but suggest that it may improve verbal memory, and Qualia Minds findings were disappointing while participants reported significant improvements across six cognitive categories, they werent significant over a placebo.35 36 37 These findings ultimately make a big impact on how we judge these supplements, and while nothings going to work perfectly for every person, they can provide insight as to the strengths and weaknesses of these products
What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation
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