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Damaged mitochondria generate large amounts of ROS whilst releasing mitochondrial DAMPs to activate PRRs, such as TLR9, thereby participating in inflammation in RA (89)

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These symptoms can include fatigue, brain fog, joint pain, and shortness of breath

chinensis polysaccharide HFD High-fat diets FA Fatty acid TGs Triglycerides AMPK Adenosine monophosphate-activated protein kinase ACC Acetyl-CoA carboxylase GN Gomisin N LXR Liver X receptor CaMKII Calmodulin-dependent protein kinase II mTOR Mammalian target of rapamycin PPARs Peroxisome proliferator-activated receptors APOs Apolipoproteins ALT Alanine aminotransferase SREBP-1c Sterol regulatory element-binding protein 1c TC Total cholesterol SCD1 Stearoyl-CoA desaturase 1 AST Aspartate aminotransferase OA Oleic acid GLUT4 Glucose transporter 4 ATP Adenosine triphosphate IRS-1 Insulin receptor substrate 1 ACP Acetyl phosphate PTP1B Protein tyrosine phosphatase 1B UGP2 UDP-glucose pyrophosphorylase 2 ROS Reactive oxygen species CYP450 Cytochrome P450 GSH Glutathione NASH Non-alcoholic steatohepatitis KEAP1 Kelch-like ECH-associated protein 1 HO-1 Heme oxygenase-1 HSC Hepatic stellate cell MDA Malondialdehyde TNF - Tumor necrosis factor- IL-1/6 Interleukin-1 beta/6 ERS Endoplasmic reticulum stress GRP78 Glucose regulatory protein 78 Glossary References 1