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Up to 80% of cirrhosis patients report poor sleep quality, as evidenced by Pittsburgh Sleep Quality Index (PSQI) scores exceeding 5 (ChildTurcottePugh [CTP] A: 16.9%, CTP B: 26.5%, and CTP C: 56.6%), and around 16 to 52% suffer from excessive daytime sleepiness (EDS), reflected by Epworth Sleepiness Scale (ESS) scores over 10 (CTP A: 17.6%, CTP B: 29.7%, CTP C: 52.8%) (31)

Incorporating this serum into a daily skin care routine can lead to significant improvements in skin tone and texture, providing a radiant and youthful appearance. The formula is packed with derm-approved ingredients for glow, including antioxidant-rich vitamin tree extract, stabilized vitamin C, niacinamide, tranexamic acid, and glutathione

Although Nrf1 is similar to Nrf2 structurally, Nrf1s activity is not controlled by Keap1 (Wang and Chan, 2006)

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