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CCLE expression data were downloaded from KEGG Calcium signaling pathway genes were downloaded from After normalization, Gene Cluster 3.0 with hierarchical clustering for cell lines was used according to Euclidean distance with complete linkage

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This review does not comprehensively address APAP toxicity in specific vulnerable populations, such as neonates, pediatric patients, pregnant women, or the elderly, who may exhibit distinct pharmacokinetics, pharmacodynamics, and susceptibility to liver injury

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