92,96,100,103 In addition, it is also efficacious in the treatment of solid tumors, such as breast cancer, 102,104 lung cancer, 97,103,105 glioma, 103,106 prostate cancer, 107 kidney cancer, 108 bladder cancer, 109 colon cancer, 110 and hepatocellular carcinoma
Gales L, Cortes L, Almeida C, Melo C V, Costa M do C, Maciel P, et al
Since studies using conditional knockout mice indicate that muscle, but not hepatic, IGF1 is a critical factor for skeletal growth (Bikle et al., 2015), it is possible that L-carnitine activates the mTOR signaling by increasing local IGF1 production
Dosage: The common dosing in studies is 1 mg of Pycnogenol per kg of body weight per day