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Third, the APP/PS1 transgenic mouse model of Alzheimers disease used in Sun 2021 to test Dihexa in an amyloid-pathology model, with Morris water maze, neuroinflammatory cytokines, and PI3K/AKT pathway activation as primary readouts

Unlike many peptides that degrade rapidly when exposed to gastric acid or enzymatic activity, this sequence demonstrates remarkable resistance to hydrolysis under acidic conditions, a property that has made it an interesting subject for laboratory research and a useful tool for studying peptide stability across a range of experimental conditions

[Abstract] Int J Biol Sci

Incorporation of slow off-rate modified aptamers reagents in single molecule array assays for cytokine detection with ultrahigh sensitivity