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Biochem Biophys Res Commun 2018 July 2;501(4):10559

Rather than acting as single-pathway inhibitors, many phytochemicals simultaneously modulate multiple upstream signals while converging on shared downstream effectors, thereby fine-tuning inflammatory intensity, stress adaptation, and survival signaling

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Intracellular ROS levels were detected by incubating cells with 10 M CM-DCFDA for 30 minutes, then analyzed by Accuri-C6 flow cytometry