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While the etiology of NTD is multifactorial, some studies have found that blood concentrations of homocysteine or holo-transcobalamin to be lower in NTD-affected infants and mothers compared to non-affected controls (reviewed in 59)

However, there are many issues that still require further investigation, such as the specific signaling pathways, as well as the type and distribution of receptors, and how SCFAs regulate immune-inflammatory responses and interact with other cytokines