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This article summary the current state of knowledge on acclimatization for various range of woody species by anatomical, physiological and biochemical levels

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However, the prevailing biological hypothesis for konzo development is that famine-stricken populations rely on diets that are deficient in the key sulfur amino acids methionine and cysteine, likely decreasing their ability to fully detoxify cyanide 10,11

Specifically, NCX4040 treatment led to increased reactive oxygen species (ROS), lipid peroxidation, and activation of ferroptosis-related genes such as CHAC1 , GPX4 , and NOX4