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To prevent radical-mediated toxicity, specific enzymes and low molecular weight substances such as glutathione (GSH) eliminate reactive species and help maintain cellular redox balance

doi: 10.1016/j.foodcont.2018.07.022 345 PrabakaranMKimSHSasirekaAChandrasekaranMChungIM

what it doesn't tolerate is multi-day gaps that drop plasma levels below therapeutic threshold before the next dose

In addition, the activity of various types of skin cells including keratinocytes, mast cells, endothelial cells, fibroblasts, and even sebocytes are associated with melasma incidence (KrupaShankar et al., 2014)