On the one hand, ID represents a major cause of hypothyroidism worldwide, and it also favors the development of goiter and thyroid nodules [6, 17, 23]
Such alterations were depicted as remarkable portal congestion, periportal inflammatory infiltrate, and moderate hepatocyte necrosis (nuclear pyknosis, karyorrhexis, and karyolysis with cytoplasmic eosinophilia), whereas the CTRL group exhibited normal architecture of liver tissue
HLPC-grade acetonitrile and methanol were obtained from Fisher Scientific (Leicester, UK) and used without further purification
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