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Corticotropin-releasing factor peptide antagonists: design, characterization and potential clinical relevance

In summary, this RCT found that GlyNAC supplementation in older adults significantly improved/corrected GSH deficiency, OxS, mitochondrial dysfunction, physical function, waist circumference, and 7 hallmarks of aging affecting mitochondria, inflammation, IR, mitophagy, genomic damage, cellular senescence, and stem cells

Emir and colleagues examined a different brain region, and their elderly sample (76.6 6.1 years) was older than ours

Peptide mechanism elucidation : The structural features of Dihexa make it a valuable probe for dissecting peptide-receptor interactions and downstream signaling pathways