la Marca G, Malvagia S, Pasquini E, Innocenti M, Donati MA, Zammarchi E
The reduction in AUC after oral administration can result from numerous mechanisms including: pH or bacterial-mediated metabolism of the drug within the GI tract, incomplete drug absorption from the GI tract, metabolism within the GI epithelium (which contains CYP3A4), excretion back into the GI tract by P-glycoprotein in the GI epithelium, hepatic metabolism, or biliary excretion into the GI tract
However, in the case of preterm delivery, since it is usually administered only for two days, adverse effects can be negligible while there is a benefit to the baby in terms of accelerated lung maturity
Rather than managing two separate vials with potentially different reconstitution batches, the BPC 157 blend consolidates both into one analytically consistent lyophilized powder