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The FEBS Journal

Maritim A, Dene BA, Sanders RA, Watkins JB

[39] [40] RSSR' + 2 GSH RSH + R'SH + GSSG where R and R' are parts of the micro-nanogel structure, and GSSG is oxidized glutathione (glutathione disulfide)

Plasma and tissue GSH levels decline with age, while markers of oxidative damage increase, creating a "redox imbalance" implicated in the pathogenesis of age-related diseases [2][3][10][11]