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The mechanisms underlying mitochondrial dysfunction include excessive generation of mitochondrial ROS (mtROS), loss of mitochondrial membrane potential, release of (mtDNA into the cytoplasm, and dysregulation of mitochondrial dynamics such as fission and fusion (Monzel et al., 2023)

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127 SFAs, such as palmitic acid, can increase the production of ceramide and NO, leading to impaired insulin synthesis, and the apoptosis of cells through inflammation, ERS, and oxidative stress, which can be blocked by unsaturated fatty acids