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Magnesium: enhancing insulin sensitivity and GLUT4 activation Magnesium is an essential intracellular mineral, playing roles in over 300 enzymatic reactions, especially those related to glucose metabolism, insulin signaling, and cellular energy production

Total glutathione lysis reagent and GSSG lysis reagent, which contains alkylating agent N-ethylmaleimide (25 mM) were prepared following manufactures protocol and added to respective wells along with blank for background

Hence, this compound plays a role in energy production

This further indicates that modulating HIF activity or inhibiting the inflammatory response of FLS in RA patients under hypoxic conditions may provide new insights for RA patient treatment strategies