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A subsequent larger RCT (n=72) confirmed these findings, showing improvements in gait speed, grip strength, exercise capacity, waist circumference, and systolic blood pressure (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]

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Consequently, ICIs targeting PD-1/PD-L1, which are currently leading agents in cancer immunotherapy, have shown considerable clinical effectiveness, including in advanced cancer cases [111]

Figure 4G,I shows that the ROS concentrations in the p53 +/+ group, the p53 / group and the CTL group increased with increasing culture time