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Protein band intensity was quantified using the ImageJ program (rsbweb.nih.gov/ij/download.html) and normalized with -actin (for total homogenate) or lamin-A (for nuclear extracts)

Multiple brain cell types have been identified to enter cellular senescence with advanced aging and/or AD including astrocytes (38), microglia (40), OPCs (37), neurons (35, 39), endothelial cells (41), and smooth muscle vascular cells (42)

15 Leptin enters the brain via active transport, which involves a short form of the leptin receptor (ObRa) at the choroid plexus

People with S1 compression often notice they cannot push off with their toes when walking, or they struggle to rise onto tiptoes on the affected side