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Unlike GLS1, GLS2 is not inhibited by CB-839 or glutamate (its immediate byproduct), and can directly bind and inhibit Rac1 (Ras-related C3 botulinum toxin substrate 1), suppressing murine and human hepatocellular carcinoma cells migration and metastasis in a mouse model [205]

Excessive supplementation can lead to imbalances in amino acid metabolism, while insufficient supplementation may not provide adequate protection against stress [48]

Brena S, Cabezas-Olcoz J, Moragues MD, et al