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For patients with frequent recurrences (more than 4 episodes per year), antibiotic prophylaxis may be consideredtypically 5-10 days every two weeks or monthly, rotating antibiotics over 2-3 months

Other symptoms can include peripheral neuropathy , characterised by weakness and pain in the limbs, and mood disturbances due to its role in neurotransmitter synthesis

Since high levels of GSTs are expressed in the hepatocytes and it has previously been demonstrated that GSTs display sulfonamidase activity, three sulfonamide prodrugs of metformin were designed and synthesized 120

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