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Cagrilintides gastric effect is inferred with reasonable confidence from receptor pharmacology, animal data, and its gastrointestinal side-effect profile, but published monotherapy trials did not center on validated gastric-emptying measurements (scintigraphy or breath testing) tracked over time

Xie A, Hanif S, Ouyang J, Tang Z, Kong N, Kim NY, et al

Source: The blood-brain barrier (BBB) is composed of specialized components called neurovascular units or NVUs, which include: Endothelial cells , which line the barrier Astrocytic endfeet , which are part of nerve cells that envelope the blood vessels Basement membrane that lines the epithelial cells Pericytes that provide structural support to the blood vessels, but may also control BBB development and permeability [1] Tight junctions seal the gap between endothelial cells in the same layer

This rescues airway hydration and has allowed mucus clearance to be restored