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Dysmenorrhea is thought to occur due to the presence of inflammatory prostaglandins and leukotrienes, which contribute to uterine contractions, increased nerve sensitivity, and a lack of muscular blood flow

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Although various therapeutic modality including systemic and topical pharmacological and procedural treatments are commonly available for melasma management, however, many of these treatments showed limited clinical response and accompany numerous unwanted adverse drug reactions

Hydration and Sleep The liver and kidneys require adequate water to process both medications and cellular waste