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50 Vaporized pure CBD has been shown to incite significantly greater subjective drug effect, pleasant drug effect, dry mouth, and throat irritated compared to oral CBD and placebo

Another limitation of the study is the use of biomarkers that are not specific to tobacco use, with the exception of total NNAL and NNN

Additionally, certain flavorants and ingredients in e-cigarette aerosols can reduce neutrophil ROS production, phagocytosis, and inflammatory signaling, with evidence indicating increased susceptibility to cell death and impaired immune responses

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