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The Collateral Damage: Allopregnanolone Allopregnanolone (ALLO) is synthesized in the brain from progesterone via a two-step pathway: Progesterone 5-dihydroprogesterone (via 5-alpha reductase) 5-DHP Allopregnanolone (via 3-HSD) Because 5-AR is the rate-limiting step, inhibiting it blocks ALLO productioneven when progesterone levels are adequate

Careful and constant monitoring of cardiovascular and respiratory (adequacy of ventilation) vital signs and the patients state of consciousness should be accomplished after each local anesthetic injection

BPC-157 reverses short bowel syndrome manifestations in animal models, promoting constant weight gain above preoperative values and increasing villus height, crypt depth, and muscle layer thickness in the remaining intestinal tissue

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