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Volume of Distribution The apparent volume of distribution reflects a balance between binding to tissues, which decreases plasma concentration and makes the apparent volume larger, and binding to plasma proteins, which increases plasma concentration and makes the apparent volume smaller

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To steer Istanbul towards a resilient, inclusive, and sustainable future, the Istanbul Planning Agency (IPA) was established in 2020, resulting in the development of the Istanbul Vision 2050 Strategic Document (2022) and the Vision 2050 Action Plan (2024), which delineate the city's key strategic actions