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For example, a study showed that lutein increased the secretion of anti-inflammatory cytokine interleukin (IL)-10 and decreased the secretion of pro-inflammatory cytokine tumor necrosis factor (TNF-) in H 2 O 2 -treated BV-2 cells [68]

(PubMed) Yang L, Calingasan NY, Wille EJ, et al

And I should mention, because I mentioned the ice bath, that of course pain threshold is something that can be built up, but it does seem that certain patterns of thinking can allow us to buffer ourselves against the pain response, and that should not be surprising