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[1], [2], [3], [4] A 2021 retrospective study conducted at the Institute for Hormonal Balance in Orlando, Florida, that evaluated the use of BPC 157, alone or in combination with thymosin-beta-4 (TB4), indicates in its methodology that no human clinical trials evaluating the use of BPC 157 to help with knee pain have been published (see Table 1)

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Tier 2: Compounding Pharmacies (Pre-2023 Landscape) Regulatory Caution Before the FDA's 2023 bulk substance notice, some 503A and 503B compounding pharmacies produced injectable BPC-157

Once the canonical axis initiates, before nuclear translocation, -catenin protein aggregates in the cytoplasm