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Methods Animals Animal experiments were performed with adherence to all national and local guidelines and regulations, the Guide for the Care and Use of Laboratory Animals 25 , and the ARRIVE guidelines, and with the approval of the Institutional Animal Care and Use Committee at The University of Texas Medical Branch (UTMB)

Common B12 deficiency symptoms include: Persistent fatigue and weakness Tingling or numbness in hands and feet Memory problems and difficulty concentrating Mood changes like irritability or depression Dizziness and balance issues Pale skin or yellowing of eyes Sore, red tongue Who is Most at Risk for B12 Deficiency

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