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Drug-Induced Thrombocytopenia: Is it a Serious Concern for Glycoprotein IIb/IIIa Receptor Inhibitors

[30] Release of GSTs as an indication of organ damage [edit] The high intracellular concentrations of GSTs coupled with their cell-specific cellular distribution allows them to function as biomarkers for localising and monitoring injury to defined cell types

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[iv] Finally, a number of additional factors may influence the design of first-in-human clinical trials, including the presence or absence of biomarkers, the suitability of the selected preclinical models, and the demographic characteristics of the study participants