Who should avoid this combination Individuals with a history of thyroid cancer or MEN 2 syndrome should not use tirzepatide, and therefore should not use this combination
As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)
Peptide therapies that stimulate the secretion of growth factors like CJC-1295, Ipamorelin, and Tesamorelin should be used cautiously in individuals with a history of cancer or uncontrolled tumor growth because these peptides may influence cell proliferation
Old standbys still help, too, like physical therapy, over-the-counter (OTC) anti-inflammatory medications, ice compresses, or topical OTC therapies like Biofreeze
