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Exercise enhances the endogenous antioxidant defense system by increasing the expression of SOD, CAT, and glutathione peroxidase (GPx), enzymes that neutralize reactive oxygen species (ROS) and prevent oxidative damage [251]
Isotope tracing showed that TCA metabolites labeled by 13 C-lactate continued to outcompete that with 13 C-glucose label in a mouse tumor model even in the presence of glucose
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