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NADPH-FSP1-CoQ10 pathway In the study of the ferroptosis-resistant cell line MCF7, the researchers screened the complementary gene for GPX4 deletion and found the apoptosis-inducing factor mitochondrial 2 (AIFM2) gene, which was initially found to induce apoptosis, and the researchers named it ferroptosis suppressor protein 1 (FSP1) [22]

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Meta-analyses show that mid-life depression is consistently associated with increased levels of inflammatory markers in blood, including C-reactive protein (CRP), Interleukin-6 (IL-6), Interleukin-1 beta (IL-1), and Tumor necrosis factor-alpha (TNF-), particularly during depressive episodes [264, 265]

and Wahren, J