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The biological plausibility of AOD9604s cartilage-regenerating effects is further supported by insights from conditions such as acromegaly, where excess GH leads to abnormally thick cartilage due to elevated local IGF-1 production

Some of the more commonly identified risk factors are below (Reinking, 2018)

Tamouza R, Volt F, Richard J-R, Wu C-L, Bouassida J, Boukouaci W, Lansiaux P, Cappelli B, Scigliuolo GM, Rafii H, Kenzey C, Mezouad E, Naamoune S, Chami L, Lejuste F, Farge D and Gluckman E (2022) Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review

Second, there are substantial differences in gut microbiota between animal models and humans