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Ddit4 deletion increased the P62 expression and decreased the LC3BII/LC3BI ratio and autophagy-related genes ( Map1lc3b and Atg5 ) within the liver, suggesting autophagy was also impaired in non-fasting mice (Fig

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This restoration of cellular energy is not a quick fix, but rather a gradual rebuilding of the body's metabolic foundation

In each case, 5FU treatment reduced the IC 50 of ETC inhibitors, demonstrating that 5FU treatment enhances dependency on ETC function