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The dose of vitamin B12 injection for adults may vary depending on the problem to be treated: Treatment of mild nerve pain : the initial dose is 5,000 IU until pain resolves Treatment of intense nerve pain: the initial dose can be increased to 15,000 IU per day and reduced by the doctor as pain resolves Treatment of pernicious anemia: the dose can vary from 100 to 1000 IU per day and the treatment time varies from person to person