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Mentioned reactive aldehydes, as well as isoprostanes, particularly F2-isoprostanes, are bioactive compounds formed via nonenzymatic peroxidation of arachidonic acid (AA), serving as reliable biomarkers for assessing oxidative stress status in various clinical conditions 89

However, there are also potential risks, especially for those with allergies or intolerances

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In the pathological study of OA, apoptosis has been observed since early times and today chondrocyte apoptosis has been suggested to be an important factor in the pathogenesis of OA (141)