E N D Presentation Transcript PHASE II DRUG METABOLISM: Glucuronidation and Sulfation General properties of Phase II metabolism Introduction to glucuronidation Substrates for UGTs UGT structure Properties of glucuronides Methods to characterize glucuronides Disposition and reactions of glucuronides UGT pharmacogenetics, polymorphism, variability Sulfotransferases N-Acetylation, Aminoacid conjugation, Glutathione conjugation Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Recommended Reading: Gonzales and Tukey, Drug Metabolism, In: Goodman and Gilmans, The Pharmacological Basis of Therapeutics, 11th Edition, 2005, Chapter 3
In order to improve the therapeutic effect of natural medicines, the research and development of natural medicines derivatives are also one of the current hot spots
Different types of presentations appearing on the market, such as capsules, elixir, creams, and even an extra virgin olive oil with a very high content of hydroxytyrosol (over 500 mg/kg)
Handy, D.E
