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The epithelial layer of the large intestine (colon) is folded into invaginated crypts of Lieberkhn that contain undifferentiated stem cells and are supported by the lamina propria (Fig

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The imidazole nitrogen of the histidine side chain donates one of the three nitrogen ligands to the copper, and the position of histidine at the second residue is what enables the deprotonated amide nitrogen of the preceding Gly-His peptide bond to also coordinate the copper

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They perform research and train physicians

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