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At the same dose, a 74 kg participant had about 1.4 times the exposure of a 110 kg reference, while a 143 kg participant had about 0.8 times. Weight alone does not set the dose, but it helps explain why the trial mean transfers poorly to bodies outside the studied range

DECIPHER (v2.6.0) was used to align sequences, and FastTree (v2.1.3) was used to generate a phylogenetic tree