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However, recent studies showed that NAC could also reverse lipid ROS levels and act as an inhibitor against ferroptosis [39, 40]

As Schwann cells are the most abundant glial cells in the peripheral nervous system, are major producers of both neurotrophins, and acquire a repairing phenotype after a nerve is damaged [68], it is plausible to hypothesize that the effects of cortistatin in neurotrophins are exerted through these cells