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Amalesh Nanda et al (75)

However, complete discontinuation typically results in weight regain, making CagriSema a long-term commitment requiring indefinite maintenance dosing

MTHFR mutations are commonly associated with high homocysteine levels 3 and low methionine production, which in turn may lead to the accumulation of S-adenosylhomocysteine (SAH) and low levels of SAMe