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The 2016 Noh investigation in International Journal of Molecular Sciences documented novel anti-melanogenesis properties of PDRN, identifying inhibition of microphthalmia-associated transcription factor (MITF) as the mechanism by which PDRN reduces melanin synthesis

For this reason, allosteric IDH inhibitors are suspected to have minimal activity against normal tissues ( 30 )

A similar database, keywords, search format, and score exam parameters were used by both reviewers

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