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10.1016/j.jinf.2021.05.004 93 KrechJ.TongG.WowroS.WalkerC.RosenthalL

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Minimize vial removal time Each time you remove vial to draw dose: Take out vial Draw dose quickly (1-2 minutes) Return to fridge immediately Don't: Leave vial on counter for 30+ minutes Warm to room temperature before drawing (unnecessary for most peptides) Forget to return to fridge (happens more than you'd think) How to tell if your reconstituted peptides have gone bad Recognition prevents using ineffective or unsafe peptides

The delivery system not only improves the water solubility and bioavailability of sorafenib, but also increases the accumulation of the drug in the tumor site through an active targeting mechanism, thereby maintaining efficacy at lower doses and reducing toxic reactions (Table 2)