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doi: 10.3390/toxics10010008 Summary Keywords olfactory receptors, chronic obstructive pulmonary disease, chronic inflammation, airway remodeling, therapeutic targets Citation Zhu Z, Gong D, Chen Y, Yuan M, Qian H, He B and Wang G (2025) A review of research advances in the modulation of olfactory receptors for COPD inflammation and airway remodeling

Its bioavailability is titrated moment-to-moment by the abundance of IGFBP-1 (which fluctuates with insulin and nutritional state), by IGFBP-3 and ALS levels (which are GH-dependent), and by IGFBP proteases that release bound IGF-1 in specific tissues

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