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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

Established the scientific basis for ARA-290s design

Worked example: 15 mg vial with 1.5 mL water Concentration: 15 mg divided by 1.5 mL = 10 mg/mL Same clean math

If concomitant use is warranted, evaluate patients for signs of diminished diuresis and/or effects on blood pressure and increase the dosage of the diuretic as needed