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For skin whitening, oral supplements such as liposomal glutathione or effervescent tablets with added Vitamin C are considered practical and relatively effective, with studies supporting their safety and some efficacy

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Borngrber S, Kuban RJ, Anton M, Khn H (1996) Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases

3,36,37 On the other hand, keratinocytes may also produce IL-23 via the actin polymerising molecule N-WASP demethylating the histone H3K9 that controls IL-23 expression