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Although a long standing search for an NO synthase (NOS) in plants similar to NOS enzymes found in mammals has thus far been unsuccessful, suppression of NO signaling in the presence of NOS inhibitors has been reported by several groups, indicating the potential existence of a NOS-like enzyme in plants (Tewari et al., 2013

First, SPI1 (also known as PU.1) is a transcription factor crucial for microglia viability and differentiation, located within a genome-wide significant AD-risk locus, where reduced expression is associated with delayed AD onset