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Hormonal variables are relevant to BPC-157 outcomes in women primarily in the context of perimenopause and menopause, where declining estrogen affects collagen synthesis rates and tissue healing capacity

Acknowledgments We thank Lauren Hayashi for assistance with experiments and Chris Riso for fish husbandry support

Thus, FOXO4-DRI targets high SASP-expressing senescent cells that have naturally developed in the kidneys of fast aging Xpd TTD/TTD mice and in doing so restores kidney homeostasis