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GPX4, a selenoenzyme that reduces phospholipid hydroperoxides (PLOOH) via GSH, prevents lipid peroxidation-induced ferroptosis ( 2+ levels, promoting lipid peroxidation, iron accumulation, and reactive oxygen species ( 2.4 Mitochondrial pathways Mitochondria, the energy-producing centers of cells, play a role in regulating energy metabolism, lipid metabolism, and iron metabolism ( 2 , thereby scavenging mitochondrial oxygen radicals and exerting anti-ferroptotic effects

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